Job title: Director, Protein Structure
Job type: Permanent
Emp type: Full-time
Location: Princeton, New Jersey
Salary type: Annual
Salary: Negotiable
Job published: 2019-04-01
Job ID: 32244
Contact name: Hannah Rogac
Contact email:

Job Description

Director, Protein Structure: Function and Translational Biomarkers

Harrison Frazer are currently working with an organization focused on the discovery and development of therapies for CNS indications. The are seeking a Science Director to join their team. 

The position is based in Princeton, New Jersey. 



  • Contribute to moving drug discovery candidates forwards, anchored on advancing human genetic validated genes that modify disease as candidate therapeutic targets
  • Refine strategic plans for experimental investigation of DNA repair and handling proteins
  • Manage network of CRO and academic scientists engaged in projects to interrogate modifier protein function, plus identify and evolve new collaborations.
  • Explore modifier protein function encompassing genetic and biochemical investigations with human cells and tissues, mouse and human stem cell platformsand in vivo studies including genetically modified animal models. 
  • Critically design experiments, analyze and synthesize data sets
  • Advance biological understanding of MoA studies of modifier proteins 
  • Provide biology co-leadership of integrated medicinal chemistry programs
  • Advance experimental approaches including established and emerging technologies in cells, tissues, and animals
  • Participate in internal and external team meetings to evaluate and advance development of target engagement and PD biomarkers
  • Identify capabilities and competencies for current and future programs in the areas of protein function, new assay development, and candidate drug molecule candidates for therapeutic advancement
  • Management/oversight of external CROs & collaborators
  • Fulfill necessary process, legal, and business requirements

Candidate Profile:

  • Ph.D. in relevant field
  • 5+ years' experience as independent scientist
  • Track record of scientific accomplishment, evidenced by refereed journal publications and securing of research funding support
  • Expertise in investigating and elucidating protein’s MoA, specifically with respect to protein:nucleic acid interactions
  • Experience and accomplishment in elucidating protein complexes and their cellular function(s), experience in design & characterization of protein isolation and characterization technologies
  • Training and experience in biophysics, structural and chemical biology, proteomics and mass spec experimental design data analysis
  • Experience in enzyme assay development & adaptation to high throughput biological assays suitable for screening
  • Significant experience planning and conducting genetic, biochemical and pharmacologic perturbation studies directed towards elucidating protein biological mechanism of action
  • Drug discovery experience in validating targets for therapeutic advancement (including program advancement of integrated medicinal chemistry optimization programs with clinical trajectory)
  • Experience in developing target engagement and PD biomarkers
  • Ability to identify, design, and drive innovative programs and demonstrated evidence of scientific “problem solving”
  • Scientific leadership, analytical skills, critical reasoning, scientific rigor, written & oral communication skills, ability to work collaboratively, self-motivated
  • Ability to travel across US and globally

If you would like to find out more about the position, please contact:

Apply in confidence.

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