Harrison Frazer are currently working with a Boston-based company focused on the development of novel cancer immunotherapies. They are seeking an experienced and knowledgeable cellular immunologist to contribute to early stage discovery, plus the future expansion of the pipeline.
The successful candidate will have a proven track record of designing and executing in vitro and in vivo assays for the identification, selection, and characterization of therapeutic antibodies against challenging immuno-oncology targets.
The ideal candidate will have laboratory experience in innate immunity, specifically either natural killer cells or myeloid cells, and the roles they play in cancer.
- Develop, validate and perform flow cytometry assays for multiparameter cell surface and intracellular analysis.
- Develop, process and analyze assays using 96/384-well plate-based immunoassay readers for both solid-phase (ELISA-type) and homogeneous (fluorescence/luminescence-based) immunoassay technologies.
- Develop and validate new assays for protein and other biomarkers in support of current or future programs using good laboratory practices to meet quality assurance standards and to optimize efficiency.
- Perform data analysis and review/audit assay data.
- Perform the isolation and analysis of primary immune cells of human and/or rodent origin.
- Conduct animal work including intraperitoneal injection, intravenous injection and orthotopic injection, tissue collection and processing.
- Support the development of new methods/SOPs for analyzing samples and the implementation of those SOPs in a timely manner with proper care and documentation.
- PhD/MS with expertise in immunology, cancer biology or related field.
- 3 years (PhD), or 5 years (MS), experience in a drug discovery setting – industry experience preferred.
- Hands-on laboratory experience with i) primary immune cells of human and/or rodent origin, ii) isolation of primary cells, iii) analysis using multi-color flow-cytometry, ELISA and other approaches.
- Hands-on laboratory experience in developing functional assays and readouts with human/rodent primary immune cells and cell lines.
- Excellent record-keeping and communication skills both verbal as well as written are essential.